Can 'permissive' hypercapnia modulate the severity of sepsis-induced ALI/ARDS?
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منابع مشابه
Effects of Permissive Hypercapnia on Pulmonary Mechanics and Hemodynamics during Mechanical Ventilation in Severe Acute Respiratory Distress Syndrome
Alveolar atelectasis and low functional residual capacity are the hallmark of the patients with acute respiratory distress syndrome (ARDS) [1]. Lots of experiments have reported that large tidal volume (VT) and traditional VT (10 12 ml/kg) can induce lung injury. In order to minimize the risk of ventilator-induced lung injury (VILI), VT should be lowered during mechanical ventilation in ARDS [1...
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Anesthesiology, V 124 • No 3 532 March 2016 O N the face of it, we have blown hot, then cold when it comes to carbon dioxide. We have tolerated it (permissive hypercapnia), considered adding it (therapeutic hypercapnia), and even at times deliberately or inadvertently decreased it.1 Advances in extracorporeal therapies, as reported in this month’s ANesthesiol...
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Hypercapnia and hypocapnia commonly complicate conditions that are present in critically ill patients. Both conditions have important physiologic effects that may impact the clinical management of these patients. For instance, hypercapnia results in bronchodilation and enhanced hypoxic vasoconstriction, leading to improved ventilation/perfusion matching. Hypocapnia reduces cerebral blood volume...
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BACKGROUND Angiopoietin-2 and vascular endothelial growth factor (VEGF) may impair vascular barrier function while angiopoietin-1 may protect it. It was hypothesised that circulating angiopoietin-2 is associated with pulmonary permeability oedema and severity of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) during septic or non-septic critical illness. METHODS Plasma leve...
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Current, lung protection strategy possesses some degree of hypercapnia and hypoxia. Permissive hypercapnia and hypoxia may attenuate the complications of mechanical ventilation in neonates. Adapting this approach and thorough understanding of the biopathologic effects of hypercapnia and hypoxia could prevent mechano-trauma and air leak syndromes. This helps protecting the lung and inflammator...
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